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Mesothelioma
Treatment
Articles
and Abstracts
Evaluation
of Membranous Staining of
Mesothelioma.
Cell
Vis 1998 Jan-Feb;5(1):24-7
King
JA, Tucker JA
University
of South Alabama Medical Center,
Department of Pathology, Mobile, USA.
jking@usamail.usouthal.edu
Panels
of immunohistochemical markers are often
used to aid in categorizing malignant
neoplasms involving the pleura. While
epithelial membrane antigen (EMA) and
human milk fat globule-2 (HMFG-2) are each
reported to stain the majority of cases of
adenocarcinoma and mesothelioma, authors
have reported that the pattern of staining
for these two antibodies can be a useful
discriminant. Both are described as
revealing a membranous pattern of staining
for mesothelioma and a cytoplasmic
staining pattern in adenocarcinoma.
Immunostains were performed on 23 cases of
malignant mesothelioma and 22 cases of
adenocarcinoma. For EMA, 78% of
mesotheliomas and 86% of adenocarcinomas
stained positively, and 65% of
mesotheliomas vs. 14% of adenocarcinomas
exhibited a membranous staining pattern.
For HMFG-2, 9% of mesotheliomas and 50% of
adenocarcinomas stained positively, and 4%
of mesotheliomas vs. 9% of adenocarcinomas
exhibited a membranous staining pattern.
Membranous staining for HMFG-2 was not a
useful criterion. In this series, a
membranous pattern of staining for EMA had
a sensitivity of 65% and a specificity of
86% for the identification of malignant
mesothelioma.
PMID:
9660721, UI: 98320097
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