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Mesothelioma
Treatment
Articles
and Abstracts
Factors
influencing the outcome of radiotherapy in
malignant mesothelioma of the pleura - a
single-institution experience with 189
patients.
Int
J Radiat Oncol Biol Phys 1999 Feb
1;43(3):511-6
de
Graaf-Strukowska L, van der Zee J, van
Putten W, Senan S
Department
of Radiation Oncology, Daniel den Hoed
Cancer Center/University Hospital
Rotterdam, The Netherlands.
PURPOSE:
To determine the factors influencing the
response to palliative radiotherapy 9RT)
in malignant mesothelioma of the pleura
(MM). METHODS AND MATERIALS: A
retrospective review was conducted of the
records of all patients with mesothelioma
who were referred to our institution
between 1979 and 1996. A total of 227 RT
series were administered to 189 patients
with MM. Of these, 21 patients with chest
wall nodules also received concomitant
local hyperthermia. RESULTS: The median
survival was 5 months from the start of RT
and only 17% of patients were alive at 1
year after treatment. Chest pain and
painful chest wall metastases were the
main indications for RT. A higher local
response rate was seen for patients
treated with a 4-Gy per fraction scheme,
vs. those receiving fractions of less than
4 Gy (50% vs. 39%). Pain recurrence
occurred predominantly within the previous
RT field, and pain recurred after a median
of 69 days (range 32-363) in the group
treated using 4-Gy fractions. When
compared with a matched group, patients
treated with combined RT and hyperthermia
had higher response rates and fewer
in-field recurrences. CONCLUSIONS: RT
provides local palliation in at least 50%
of patients with MM who were treated using
a 4-Gy/fraction scheme to a media dose of
36 Gy. The low response rates with RT
alone suggest that combined RT and local
hyperthermia should be further evaluated
in MM.
PMID:
10078630, UI: 99176516
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