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Mesothelioma
Treatment
Articles
and Abstracts
Pathology
of human malignant
mesothelioma--preliminary analysis of
1,517 mesothelioma cases.
Ind
Health 2001 Apr;39(2):183-5
Suzuki
Y.
Department
of Community and Preventive Medicine,
Mount Sinai School of Medicine, New York,
New York, 10029, USA.
The
author reviewed 1,517 human malignant
mesothelioma cases from 1975 through
August 2000. These mesothelioma cases were
definite or probable in diagnostic
certainty. Sources of these cases varied
including asbestos insulation workers,
UNARCO workers, Cancer and Leukemia B
mesothelioma panel cases and random cases.
Pathology materials consisted of autopsy,
biopsy and rare cytology specimens. 92.3%
of these patients were male, and 85.8%
were between 50 and 79 years in age. The
major primary site of the tumor was the
pleura (73.1%). However, in a group of the
asbestos insulation workers, the
peritoneum was the more common primary
site of malignant mesothelioma, compared
to the pleura. Histologically, epithelial
cell type was the majority (61.1%),
followed by biphasic (22.1%) and
fibrosarcomatous (16.4%). A double primary
tumor (malignant mesothelioma associated
with other cancer) was present in 32 of
the 1,517 cases. These 32 cancers included
lung cancers, renal cell carcinomas,
colorectal cancers, pancreatic cancers and
a cancer of the larynx, which are known to
be at higher risk among asbestos
insulation workers. The latency period of
the vast majority (98.1%) of these
mesothelioma cases were longer than 20
years. It is well accepted that cigarette
smoking does not contribute to the
induction of malignant mesothelioma.
Indeed, the present study confirmed that
19.9% of these mesothelioma patients had
never smoked cigarettes.
PMID:
11341549 [PubMed - indexed for
MEDLINE]
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